Which enzyme covalently links DNA ends together, connecting Okazaki fragments?

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Multiple Choice

Which enzyme covalently links DNA ends together, connecting Okazaki fragments?

Explanation:
Sealing nicks to make a continuous DNA strand is done by DNA ligase. On the lagging strand, DNA is made in short fragments called Okazaki fragments. After each fragment is synthesized, RNA primers are removed and the gaps filled in, and then DNA ligase covalently joins the ends by forming a phosphodiester bond between the 3' OH of one fragment and the 5' phosphate of the next. This restores the sugar-phosphate backbone and makes the strand continuous. DNA polymerase builds DNA strands but doesn’t join fragments; RNA polymerase makes RNA primers; helicase unwinds the DNA.

Sealing nicks to make a continuous DNA strand is done by DNA ligase. On the lagging strand, DNA is made in short fragments called Okazaki fragments. After each fragment is synthesized, RNA primers are removed and the gaps filled in, and then DNA ligase covalently joins the ends by forming a phosphodiester bond between the 3' OH of one fragment and the 5' phosphate of the next. This restores the sugar-phosphate backbone and makes the strand continuous.

DNA polymerase builds DNA strands but doesn’t join fragments; RNA polymerase makes RNA primers; helicase unwinds the DNA.

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